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Richard C Becker Selected Research

Factor IXa (Coagulation Factor IXa)

9/2019Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes.
1/2016Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.
8/2014Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study.
8/2011Factor IXa as a target for pharmacologic inhibition in acute coronary syndrome.
12/2009REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis.
6/2008Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.

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Richard C Becker Research Topics

Disease

100Hemorrhage
11/2021 - 07/2004
91Stroke (Strokes)
10/2021 - 11/2002
84Acute Coronary Syndrome
04/2022 - 05/2002
67Atrial Fibrillation
10/2021 - 02/2005
58Thrombosis (Thrombus)
01/2022 - 05/2002
52Myocardial Infarction
01/2021 - 09/2002
42Embolism (Embolus)
10/2021 - 11/2005
18Coronary Artery Disease (Coronary Atherosclerosis)
01/2019 - 09/2004
16Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 12/2004
14Heart Failure
12/2020 - 10/2004
12Thrombocytopenia (Thrombopenia)
01/2022 - 02/2005
11Myocardial Ischemia (Ischemic Heart Diseases)
02/2020 - 01/2008
10Inflammation (Inflammations)
12/2020 - 02/2003
6Intracranial Hemorrhages (Intracranial Hemorrhage)
10/2021 - 09/2011
5Venous Thromboembolism
01/2020 - 07/2006
5Ischemic Stroke
01/2019 - 12/2003
5Body Weight (Weight, Body)
01/2017 - 05/2002
5Hypersensitivity (Allergy)
12/2016 - 09/2004
5ST Elevation Myocardial Infarction
06/2015 - 02/2003
5Transient Ischemic Attack
05/2014 - 11/2005
5Coronary Disease (Coronary Heart Disease)
05/2013 - 05/2002
4Thromboembolism
01/2020 - 06/2008
4Atherosclerosis
01/2020 - 02/2003
4Anemia
04/2017 - 04/2006
4Chronic Renal Insufficiency
09/2013 - 09/2010
4Thrombophilia
11/2012 - 04/2006
3COVID-19
01/2022 - 11/2021
3Neoplasms (Cancer)
12/2020 - 04/2006
3Obesity
12/2019 - 03/2010
3Peripheral Vascular Diseases (Peripheral Vascular Disease)
01/2019 - 12/2003
3Chronic Obstructive Pulmonary Disease (COPD)
06/2017 - 03/2014
3Atherosclerotic Plaque (Atheroma)
06/2015 - 05/2002
3Hemorrhagic Stroke
07/2014 - 10/2012
3Ischemia
12/2013 - 12/2009
3Renal Insufficiency (Renal Failure)
08/2013 - 09/2010
3Unstable Angina
10/2010 - 03/2004
3Heart Diseases (Heart Disease)
12/2009 - 01/2009
2Cardiotoxicity
12/2020 - 07/2011
2Atrial Flutter (Flutter, Atrial)
10/2020 - 09/2014
2Cardiomyopathies (Cardiomyopathy)
01/2020 - 01/2020

Drug/Important Bio-Agent (IBA)

57Warfarin (Coumadin)FDA LinkGeneric
01/2021 - 07/2005
48RivaroxabanIBA
10/2021 - 09/2011
46Clopidogrel (Plavix)FDA Link
04/2022 - 09/2004
40AnticoagulantsIBA
10/2020 - 05/2002
38TicagrelorIBA
04/2022 - 09/2009
34Vitamin KFDA Link
10/2021 - 06/2012
34Factor Xa (Coagulation Factor Xa)IBA
10/2021 - 05/2002
32Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
11/2021 - 05/2002
23Heparin (Liquaemin)FDA LinkGeneric
08/2014 - 05/2002
22Biomarkers (Surrogate Marker)IBA
01/2022 - 02/2005
19Pharmaceutical PreparationsIBA
01/2016 - 02/2003
11Factor Xa InhibitorsIBA
01/2020 - 05/2002
9CreatinineIBA
03/2016 - 09/2010
8Growth Differentiation Factor 15IBA
01/2020 - 01/2014
8Glycoproteins (Glycoprotein)IBA
01/2019 - 08/2004
8EscitalopramFDA Link
01/2017 - 01/2012
7Proteins (Proteins, Gene)FDA Link
02/2020 - 07/2002
7RB 006IBA
09/2019 - 12/2009
7Enoxaparin (Lovenox)FDA LinkGeneric
02/2011 - 05/2002
6Brain Natriuretic Peptide (Natrecor)FDA Link
06/2020 - 11/2012
6apixabanIBA
01/2020 - 06/2009
6Cystatin CIBA
12/2019 - 01/2012
6pro-brain natriuretic peptide (1-76)IBA
12/2019 - 01/2014
6Factor IXa (Coagulation Factor IXa)IBA
09/2019 - 06/2008
6ThrombinFDA Link
01/2012 - 05/2002
5Troponin T (Troponin T1)IBA
06/2020 - 04/2016
5Purinergic P2Y Receptor AntagonistsIBA
06/2017 - 01/2009
5Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
08/2015 - 02/2005
5Biological ProductsIBA
10/2013 - 02/2005
5Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
02/2012 - 06/2008
5Peptide Hydrolases (Proteases)FDA Link
01/2012 - 06/2005
4von Willebrand FactorIBA
11/2021 - 02/2012
4C-Reactive ProteinIBA
06/2020 - 06/2005
4Adenosine Diphosphate (ADP)IBA
11/2016 - 03/2006
4AntithrombinsIBA
01/2014 - 02/2008
4Hemostatics (Antihemorrhagics)IBA
02/2011 - 04/2006
3VaccinesIBA
01/2022 - 04/2006
3bivalirudin (Angiomax)FDA Link
11/2021 - 04/2012
3Histones (Histone)IBA
02/2020 - 01/2014
3DNA (Deoxyribonucleic Acid)IBA
01/2020 - 01/2014
3Nucleotide AptamersIBA
09/2019 - 06/2008
3AntidotesIBA
01/2019 - 12/2006
3Tissue Plasminogen Activator (Alteplase)FDA Link
11/2017 - 12/2009
32'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA
04/2017 - 01/2012
3StreptokinaseFDA Link
04/2017 - 07/2004
3RB 007IBA
01/2016 - 12/2009
3vorapaxarIBA
05/2014 - 03/2009
3Thromboplastin (Tissue Factor)IBA
01/2014 - 08/2004
3CollagenIBA
01/2014 - 11/2009
3(2S)- 2- (4- (((3S)- 1- acetimidoyl- 3- pyrrolidinyl)oxy)phenyl)- 3- (7- amidino- 2- naphtyl)propanoic acidIBA
01/2006 - 05/2002
2Insulin (Novolin)FDA Link
06/2021 - 04/2006

Therapy/Procedure

67Therapeutics
12/2021 - 05/2002
19Percutaneous Coronary Intervention
09/2019 - 03/2006
15Stents
11/2021 - 02/2008
13Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/2018 - 03/2008
9Drug Therapy (Chemotherapy)
06/2021 - 06/2008
7Thrombolytic Therapy
11/2017 - 02/2003
5Catheters
12/2013 - 10/2009
5Secondary Prevention
11/2010 - 01/2008
3Prostheses and Implants (Prosthesis)
01/2020 - 12/2014